Feb 25, 2022
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Synadrene By Hi-Tech Pharmaceuticals (Review)

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What Is Synadrene | Original Synadrene Ingredients | Synadrene In 2021 | Synadrene Benefits | Synadrene Reviews | How To Take
The post Synadrene By Hi-Tech Pharmaceuticals (Review) appeared first on Supplement Reviews Blog.


What Is Synadrene | Original Synadrene Ingredients | Synadrene In 2021 | Synadrene Benefits | Synadrene Reviews | How To Take It | Similar To Synadrene | Synadrene VS HydroxyeliteSide Effects And Warnings | Disclaimer

When it comes your weight loss journey, picking the right fat burner can be what takes your results to the next level. But knowing what to look for isn’t always simple, especially when formulas change often. Fortunately, that’s why we’re here! In this post, we’re going over Synadrene by Hi-Tech Pharmaceuticals and we’ll cover some popular FAQ’s like what’s changed since it was released 2016.

What is Synadrene?

Synadrene by Hi-Tech Pharmaceuticals is a top class fat burner that replicates a discontinued fat burner, Metabolic Nutrition’s Synedrex. Similar to Synedrex, Synadrene had a revision from a version with the addition of 1,3-Dimethylamylamine HCL (DMAA) to 2-Aminoisoheptane (DMHA). Synadrene can be used by anyone looking to burn some extra calories, get that extra edge in their routine, shed fat, maintain muscle or to have more energy during the day.†

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The Original Synadrene Ingredients:

You will notice an increase in energy from these B vitamins. The chromium will help insulin transport glucose into cells which in return will also be used for energy.

  • Vitamin B12
  • Vitamin B3
  • Chromium
  • Vitamin B6

Synadrene Proprietary blends:

  •  Methylxanthine
  • Green Tea Extract
  • DMAA
  •  Sulbutiamine
  •  Sandalwood Extract
  •  Yohimbine Extract
  •  Alpha Lipoic Acid
  •  Poly-Thyronine

Methylxanthine is a mild stimulant that include caffeine, theophylline, and theobromine. (1) Unfortunately, this version of Synadrene doesn’t state what type of stimulant Methylxanthine is. Though, often in dietary supplements it represents caffeine on the label. The next ingredient, Green Tea Extract, is a very potent antioxidant. It also acts as a thermogenic meaning it will increase thermogenesis in the body. (2)

Next is the 1,3-Dimethylamylamine HCl (DMAA) which was a strong stimulant. With the DMAA you’ll notice increased energy and focus. (3) Sulbutiamine is a great nootropic and also an appetite suppressant. It also really helps with alertness, tackling down that ” brain fog” feeling. (4)

Sandalwood Extract may help with muscle cramping and shows promise as an anti-diabetic (5). Yohimbine Extract may help with stubborn fat areas by increasing fat utilization (6). Alpha Lipoic Acid (ALA) is another antioxidant. Studies suggest that ALA may have some anti-obesity properties, which may result in some weight loss. (7) Finally, Poly-Thyronine is a combination of thyroid hormone metabolites T2. In term of fat loss, this ingredient may boost metabolism and reduce appetite (8).

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Why Remove DMAA?

In August 2018, DMAA was no longer considered a dietary supplement by the US FDA. Therefore, products containing it had to be reformulated. (9) Synadrene wasn’t the only product affected by this change. Other popular fat burners like Hydroxyelite and Lipodrene were also reformulated. Along with changes in pre workouts like Mesomorph.

If you’d like to read more about the change and DMHA, checkout our blog HERE!

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Synadrene In 2021:


This formula features:

  • Caffeine
  • Green Tea Extract
  • 2-Aminoisoheptane HCl (DMHA)
  • Walnut Extract
  • Sulbutiamine
  • Sandalwood Extract
  • Yohimbe Extract
  • Alpha Lipoic Acid
  • Poly-Thyronine.

As you can see most of the ingredients have stayed the same after change. In fact, the only formula change is the addition of DMHA and Walnut Extract and removal of DMAA. Visually, we can also see the Methylxanthine has been changed to Caffeine. But overall, the ingredient blends and mgs are the same across the versions.  DMHA is actually sourced from the walnut tree, so by including both DMHA and Walnut Extract to Synadrene, the effects if DMHA may be amplified. (10)

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Synadrene Benefits:

Synadrene is high-stim fat burner. Because of this many of the benefits you may experience will stem from the stimulant. Those benefits can include increased energy, mood/focus boost, improved metabolism, and appetite suppression. Though based on our customer feedback, the most prominent effect of Synadrene in 2021 is the appetite suppression!

Of course, individual results and effects will vary, but let’s checkout some customer feedback too!


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Synadrene Reviews:


  • Review By Kendra:
I am a huge oxy elite pro fan. Well I must say this one might be even better. Especially in the energy department.” (Posted On 10/21/21)

  • Review By Kristina:
Works very well as appetite suppressant and as well as energy. I only take 1 on random days I’m the morning because otherwise it’s too strong (up to 4 a day as recommended on bottle is way too much). Thanks for your speedy delivery and free shipping! Very reliable :)” (Posted On 11/30/20)

  • Review By Emily:
In 8 months I’ve lost 65lbs. I take 1 a day (on occasion I have taken 2). It gives me energy and I really like how much I sweat! It really intensifies a workout or just work period. My appetite is curbed and when I eat I make better choices about what I eat because I’m not really hungry. I do have to take this product with a small meal otherwise I feel a little shakey but a quick bite fixes that.” (Posted On 10/13/20)

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How To Take It :

Take 1 capsules three times daily.  Do not exceed 4 capsules in any 24-hour period.


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Similar To Synadrene:

lean efx

Unfortunately, much like when DMAA became unavailable in 2018 and caused major delays to fat burners, Synadrene is currently unavailable in November 2021. This however, is not because of FDA court cases with DMHA but instead is related to delays in importing DMHA. (11)

But that’s why we’re here to provide you updated information and provide recommendations!

For starters, if you like Synadrene you may find Synedrex from Metabolic Nutrition to be good alternative. Read more about Synedrex HERE!

Synadrene VS Hydroxyelite:

As we mentioned previously, Hydroxyelite and Synadrene were both affected by the removal of DMAA and as a result both formulas now contain DMHA. Like Synadrene, Hydroxyelite is often famed for it’s appetite suppression properties. So which Hi-Tech fat burner is better?

HydroxyElite Ingredients


Above we have the label for the current version of Hydroxyelite. If you’d like to read more about Hydroxyelite’s previous formula click HERE. Or about how it compares to Oxyelite Pro, click HERE.

From the label, we see Hydroxyelite contains:

  • Bauhinia Extract
  • Bacopa Extract
  • Walnut Bark Extract
  • Cirsium Oligophyllum Extract
  • Rauwolscine Extract
  • Garcinia Cambogia Extract
  • DMHA
  • Caffeine

When compared to Synadrene, there are 3 ingredients that are directly shared; Caffeine, DMHA, and Walnut Bark Extract. There is also a fourth ingredient pair that is similar: Yohimbe and Rauwolscine.

Rauwolscine is actually a metabolite of Yohimbine. In which main way is through blocking alpha-2 adrenergic receptors located in fat cells. Once yohimbine has bound with a fat cell, it “turns off” the alpha receptor. Which allows the fat cells to mobilize and burn off (12).

The other ingredients in Hydroxyelite dive in categories like thermogenesis, mood/focus, and appetite suppression.

Is Hydroxyelite Better:

After comparing the labels and reviews, we would say Hydroxyelite may be better for individuals looking for a potent appetite suppressant. However, we would expect Synadrene to be better suited for individuals looking for a fat burner to promote energy and thermogenesis. Lastly, we would expect the focus and mood boosting properties to be more prominent in Hydroxyelite from ingredients like Bacopa Extract.

If you’re looking for an alternative to these fat burners or just a better appetite suppressant, we recommend checking out Methyldrene Elite.

For information on how Hydroxyelite and Methyldrene Elite compare, checkout our blog!

methyldrene-elite-ephedra pills

This wraps up the end of our comparison of Synadrene. Thank you for reading and if you have any question, need a recommendation, or have a topic you want us to cover in a future blog, let us know HERE!


For more information on the previous version of Synadrene, Checkout Trainer Joe B’s Video!

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Side Effects And Warning:

Not for use by individuals under the age of 18 years. Do not use if you are pregnant or nursing. This product can raise blood pressure and interfere with other drugs you may be taking. Talk to your doctor about this product. Individuals who consume caffeine with this product may experience serious adverse health effects. Individuals who are sensitive to the effects of caffeine should consult a licensed health care professional before consuming this product.

Do not consume synephrine or caffeine from other sources, including but not limited to, coffee, tea, soda, or other dietary products, or medications containing caffeine or phenylephrine. Do not use for more than 8 weeks.

Consult with your physician prior to use if you are taking medication, including but not limited to MAOI inhibitors, Aspirin, antidepressants, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

Consult your physician prior to use if you have a medical condition, including but not limited to heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate, or glaucoma.

Discontinue 2 weeks prior to surgery or if you experience rapid heartbeat, dizziness, severe headache, or shortness of breath. In case of accidental overdose, seek professional assistance or contact a poison control center immediately.

Avoid alcohol while taking this product. Exceeding recommended serving may cause serious adverse health effects, including heart attack and stroke. Improper use of this product may be hazardous to a person’s health.

This product may contain ingredients that are banned by some sports organizations and/or increase risk of false positive on a drug test. Please consult with your sport organization or physician before taking this product.


†The intention of the information provided is for reference only and we are in no way providing medical advice or instruction. The information provided in this post is based on anecdotal information and available studies/reviews. While it is our goal to maintain and display accurate information, we can’t guarantee it represents the latest formulation of the product or information. Therefore, if you have any concerns, please visit the manufacturer’s website. Also, the information above is not a representation of our views at Same Day Supplements. Rather, these are the views and information provided by manufacturers and users. Also, the Food and Drug Administration has not evaluated these statements. Finally, the intention of these products is not to diagnose, treat, cure or prevent any disease or illness.

The post Synadrene By Hi-Tech Pharmaceuticals (Review) appeared first on Supplement Reviews Blog.


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